Calnexin est un gène codé par le symbole CANX. D'autres noms incluent: IP90; Major histocompatibility complex class I antigen-binding protein p88; p90; CANX. Calnexin a une masse de 67.57kDa et une longueur d'acide aminé de 592.
Nous proposons 22 des anticorps contre Calnexin, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Porcin, Lapin, Singe, Mouton, Poulet, Canin, Drosophile, Cochon d'Inde, Hamster et Xenopus.
Informations sur les Gènes et les Protéines
Résumé UniProt
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
Résumé Entrez
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described.
Similitudes de séquence
Belongs to the calreticulin family.
Modification post-traductionnelle
Phosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity).
Localisation cellulaire
Endoplasmic reticulum membrane. Endoplasmic reticulum. Melanosome.
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232).
