Carboxypeptidase H est un gène codé par le symbole CPE. D'autres noms incluent: Carboxypeptidase E; CPE; CPH; Enkephalin convertase; Prohormone-processing carboxypeptidase. Carboxypeptidase H a une masse de 53.15kDa et une longueur d'acide aminé de 476.
Nous proposons 7 des anticorps contre Carboxypeptidase H, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.
Résumé Entrez
This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes.
Spécificité tissulaire
Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas.
Similitudes de séquence
Belongs to the peptidase M14 family.
Localisation cellulaire
Cytoplasmic vesicle > Secretory vesicle. Cytoplasmic vesicle > Secretory vesicle membrane. Secreted.
Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions.
