CD11c est un gène codé par le symbole ITGAX. D'autres noms incluent: Integrin alpha-X; CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; ITGAX. CD11c a une masse de 127.83kDa et une longueur d'acide aminé de 1163.
Nous proposons 33 des anticorps contre CD11c, élevé dans Lapin, Souris et Hamster, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Singe, Mouton, Canin, Goat et Raccoon.
Informations sur les Gènes et les Protéines
Résumé UniProt
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
Résumé Entrez
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Predominantly expressed in monocytes and granulocytes.
Similitudes de séquence
Belongs to the integrin alpha chain family.
Localisation cellulaire
Membrane.
