CD300 antigen est un gène codé par le symbole CD300A. D'autres noms incluent: CMRF35-like molecule 8; CLM-8-like family member A; CMRF-35-H9; CMRF35-H9; CMRF35-H; IRC1/IRC2; Immunoglobulin superfamily member 12; IgSF12; Inhibitory receptor protein 60; IRp60; NK inhibitory receptor; CD300A; CMRF35H; IGSF12. CD300 antigen a une masse de 33.2kDa et une longueur d'acide aminé de 299.
Nous proposons 8 des anticorps contre CD300 antigen, élevé dans Lapin et Souris, qui sont appropriés pour le WB et Cytométrie en Flux avec des échantillons dérivés de Humain.
Informations sur les Gènes et les Protéines
Résumé UniProt
Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923).
Résumé Entrez
This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.
Similitudes de séquence
Belongs to the CD300 family.
Modification post-traductionnelle
Phosphorylated on tyrosine.
Localisation cellulaire
Cell membrane.
