CD86 est un gène codé par le symbole CD86. D'autres noms incluent: T-lymphocyte activation antigen Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1; CD28LG2. CD86 a une masse de 37.68kDa et une longueur d'acide aminé de 329.
Nous proposons 65 des anticorps contre CD86, élevé dans Lapin, Souris et Rat, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat, Bovin et Mouton.
Informations sur les Gènes et les Protéines
Résumé UniProt
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
Résumé Entrez
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.
Spécificité tissulaire
Expressed by activated B-lymphocytes and monocytes.
Modification post-traductionnelle
Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
Localisation cellulaire
Cell membrane.
