CDX2 est un gène codé par le symbole CDX2. D'autres noms incluent: Homeobox protein CDX-2; CDX-3; Caudal-type homeobox protein 2; CDX3. CDX2 a une masse de 33.52kDa et une longueur d'acide aminé de 313.
Nous proposons 47 des anticorps contre CDX2, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris, Rat et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536).
Résumé Entrez
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis.
Similitudes de séquence
Belongs to the Caudal homeobox family.
Modification post-traductionnelle
Phosphorylation of Ser-60 mediates the transactivation capacity.
Localisation cellulaire
Nucleus.
