Ceruloplasmin est un gène codé par le symbole CP. D'autres noms incluent: Ferroxidase; CP. Ceruloplasmin a une masse de 122.21kDa, une longueur d'acide aminé de 1065, et est impliqué dans Aceruloplasminemia.
Nous proposons 10 des anticorps contre Ceruloplasmin, élevé dans Lapin, Chèvre et Sheep, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, IP et Dot avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity).
Résumé Entrez
The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
Spécificité tissulaire
Expressed by the liver and secreted in plasma.
Implication dans la maladie
Aceruloplasminemia: An autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.
Similitudes de séquence
Belongs to the multicopper oxidase family.
Localisation cellulaire
Secreted.
Colocalizes with GCP1 in secretory intracellular compartments.
