CNTN4 est un gène codé par le symbole CNTN4. D'autres noms incluent: Contactin-4; Brain-derived immunoglobulin superfamily protein 2; BIG-2. CNTN4 a une masse de 113.45kDa et une longueur d'acide aminé de 1026.
Nous proposons 4 des anticorps contre CNTN4, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
Résumé Entrez
This gene encodes a member of the contactin family of immunoglobulins. Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity. The encoded protein is a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in the formation of axon connections in the developing nervous system. Deletion or mutation of this gene may play a role in 3p deletion syndrome and autism spectrum disorders. Alternative splicing results in multiple transcript variants.
Spécificité tissulaire
Mainly expressed in brain. Highly expressed in cerebellum and weakly expressed in corpus callosum, caudate nucleus, amygdala and spinal cord. Also expressed in testis, pancreas, thyroid, uterus, small intestine and kidney. Not expressed in skeletal muscle. Isoform 2 is weakly expressed in cerebral cortex.
Similitudes de séquence
Belongs to the immunoglobulin superfamily. Contactin family.
Localisation cellulaire
Cell membrane. Secreted.
