CPI17 alpha est un gène codé par le symbole PPP1R14A. D'autres noms incluent: Protein phosphatase 1 regulatory subunit 14A; 17 kDa PKC-potentiated inhibitory protein of PP1; Protein kinase C-potentiated inhibitor protein of 17 kDa; CPI-17; PPP1R14A; CPI17; PPP1INL. CPI17 alpha a une masse de 16.69kDa et une longueur d'acide aminé de 147.
Nous proposons 7 des anticorps contre CPI17 alpha, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Résumé Entrez
The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Spécificité tissulaire
Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.
Similitudes de séquence
Belongs to the PP1 inhibitor family.
Localisation cellulaire
Cytoplasm.
