EB2 est un gène codé par le symbole MAPRE2. D'autres noms incluent: Microtubule-associated protein RP/EB family member 2; APC-binding protein End-binding protein 2; MAPRE2; RP1. EB2 a une masse de 37.03kDa, une longueur d'acide aminé de 327, et est impliqué dans Skin creases, congenital symmetric circumferential, 2.
Nous proposons 3 des anticorps contre EB2, élevé dans Lapin et Rat, qui sont appropriés pour le WB, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).
Résumé Entrez
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants.
Spécificité tissulaire
Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes.
Implication dans la maladie
Skin creases, congenital symmetric circumferential, 2: An autosomal dominant disease characterized by multiple, symmetric, circumferential rings of folded skin, affecting primarily the limbs. Affected individuals also exhibit intellectual disability, cleft palate, and dysmorphic features.
Similitudes de séquence
Belongs to the MAPRE family.
Localisation cellulaire
Cytoplasm > Cytoskeleton.
Associated with the microtubule network. Accumulates at the plus end of microtubules.
