Endostatin est un gène codé par le symbole COL15A1. D'autres noms incluent: Collagen alpha-1(XV) chain; COL15A1. Endostatin a une masse de 141.72kDa et une longueur d'acide aminé de 1388.
Nous proposons 9 des anticorps contre Endostatin, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et sELISA avec des échantillons dérivés de Humain et Souris.
Informations sur les Gènes et les Protéines
Résumé UniProt
Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle.
Résumé Entrez
This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration.
Spécificité tissulaire
Expressed predominantly in internal organs such as adrenal gland, pancreas and kidney.
Similitudes de séquence
Belongs to the multiplexin collagen family.
Modification post-traductionnelle
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Localisation cellulaire
Secreted > Extracellular space > Extracellular matrix.
