Fatty Acid Binding Protein 5 est un gène codé par le symbole FABP5. D'autres noms incluent: Fatty acid-binding protein 5; Epidermal-type fatty acid-binding protein; E-FABP; Fatty acid-binding protein, epidermal; Psoriasis-associated fatty acid-binding protein homolog; PA-FABP; FABP5. Fatty Acid Binding Protein 5 a une masse de 15.16kDa et une longueur d'acide aminé de 135.
Nous proposons 12 des anticorps contre Fatty Acid Binding Protein 5, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed:22170058, PubMed:21395585). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). May be involved in keratinocyte differentiation (PubMed:8092987).
Résumé Entrez
This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.
Spécificité tissulaire
Keratinocytes; highly expressed in psoriatic skin (PubMed:8092987). Expressed in brain gray matter (PubMed:21395585).
Similitudes de séquence
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Localisation cellulaire
Cytoplasm. Nucleus. Cell junction > Synapse. Cell junction > Synapse > Postsynaptic density. Secreted.
Localizes primarily to the cytoplasm. Upon certain ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into nucleus (PubMed:24692551). Secreted by astrocytes, but not by neurons (By similarity).
