FCRL2 est un gène codé par le symbole FCRL2. D'autres noms incluent: Fc receptor-like protein 2; FcR-like protein 2; Fc receptor homolog 2; FcRH2; IFGP family protein 4; Immunoglobulin receptor translocation-associated protein 4; SH2 domain-containing phosphatase anchor protein 1; FCRH2; IFGP4; IRTA4; SPAP1. FCRL2 a une masse de 55.54kDa et une longueur d'acide aminé de 508.
Nous proposons 2 des anticorps contre FCRL2, élevé dans Souris et Chèvre, qui sont appropriés pour le WB, ELISA et Cytométrie en Flux avec des échantillons dérivés de Humain.
Informations sur les Gènes et les Protéines
Résumé UniProt
May have an regulatory role in normal and neoplastic B cell development.
Résumé Entrez
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Spécificité tissulaire
Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B-cell lines. Preferentially expressed in memory B-cells (at protein level).
Modification post-traductionnelle
Isoform 2 is N- and O-glycosylated, and phosphorylated.
Localisation cellulaire
Cell membrane.
