Fibrillarin est un gène codé par le symbole FBL. D'autres noms incluent: rRNA 2'-O-methyltransferase 34 kDa nucleolar scleroderma antigen; Histone-glutamine methyltransferase; FBL; FIB1; FLRN. Fibrillarin a une masse de 33.78kDa et une longueur d'acide aminé de 321.
Nous proposons 11 des anticorps contre Fibrillarin, élevé dans Lapin, Souris, Chèvre et Poulet, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat, Singe, C. elegans, Canin, Drosophile, Cheval, S. cerevisiae et Poisson Zèbre.
Informations sur les Gènes et les Protéines
Résumé UniProt
S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (PubMed:24352239, PubMed:30540930). Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (PubMed:30540930). Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239, PubMed:30540930).
Résumé Entrez
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.
Similitudes de séquence
Belongs to the methyltransferase superfamily. Fibrillarin family.
Modification post-traductionnelle
Ubiquitinated. Ubiquitination leads to proteasomal degradation (PubMed:19208757). Deubiquitinated by USP36 (PubMed:19208757).
Localisation cellulaire
Nucleus > Nucleolus.
Fibrillar region of the nucleolus.
