GAD65 est un gène codé par le symbole GAD2. Communément appelé aussi: Glutamate decarboxylase 2; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoform; GAD2. GAD65 a une masse de 65.41kDa et une longueur d'acide aminé de 585.
Nous proposons 27 des anticorps contre GAD65, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, IP et RIA avec des échantillons dérivés de Humain, Souris, Rat et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
Catalyzes the production of GABA.
Résumé Entrez
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
Similitudes de séquence
Belongs to the group II decarboxylase family.
Modification post-traductionnelle
Phosphorylated; which does not affect kinetic parameters or subcellular location.
Localisation cellulaire
Cytoplasm > Cytosol. Cytoplasmic vesicle. Cell junction > Synapse > Presynaptic cell membrane. Golgi apparatus membrane.
Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
