GNAT2 est un gène codé par le symbole GNAT2. Communément appelé aussi: Guanine nucleotide-binding protein G(t) subunit alpha-2; Transducin alpha-2 chain; GNATC. GNAT2 a une masse de 40.18kDa, une longueur d'acide aminé de 354, et est impliqué dans Achromatopsia 4.
Nous proposons 5 des anticorps contre GNAT2, élevé dans Lapin, qui sont appropriés pour le WB, ELISA et ICC/IF avec des échantillons dérivés de Humain et Souris.
Informations sur les Gènes et les Protéines
Résumé UniProt
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
Résumé Entrez
Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones.
Spécificité tissulaire
Retinal rod outer segment.
Implication dans la maladie
Achromatopsia 4: An ocular stationary disorder due to the absence of functioning cone photoreceptors in the retina. It is characterized by total colorblindness, low visual acuity, photophobia and nystagmus.
Similitudes de séquence
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Localisation cellulaire
Cell projection > Cilium > Photoreceptor outer segment. Photoreceptor inner segment.
Localizes mainly in the outer segment in the dark-adapted state, whereas is translocated to the inner part of the photoreceptors in the light-adapted state. During dark-adapted conditions, in the presence of UNC119 mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light.
