GST est un gène codé par le symbole GSTA1. Communément appelé aussi: Glutathione S-transferase A1; 13-hydroperoxyoctadecadienoate peroxidase; Androst-5-ene-3,17-dione isomerase HA subunit 1 class-alpha member 1-epsilonA1-1; GTH1A1. GST a une masse de 25.63kDa et une longueur d'acide aminé de 222.
Nous proposons 27 des anticorps contre GST, élevé dans Lapin, Souris, Chèvre et Rat, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, IP, Dot et ChIP avec des échantillons dérivés de Humain.
Informations sur les Gènes et les Protéines
Résumé UniProt
Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686). Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487).
Résumé Entrez
This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants.
Spécificité tissulaire
Liver.
Similitudes de séquence
Belongs to the GST superfamily. Alpha family.
Localisation cellulaire
Cytoplasm.
