Histone H2B est un gène codé par le symbole H2BC12. Communément appelé aussi: Histone H2B type 1-K; H2B K; HIRA-interacting protein 1; H2BC12; H2BFT; HIRIP1; HIST1H2BK. Histone H2B a une masse de 13.89kDa et une longueur d'acide aminé de 126.
Nous proposons 42 des anticorps contre Histone H2B, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, IP et ChIP avec des échantillons dérivés de Humain, Souris, Rat, Singe et S. pombe.
Informations sur les Gènes et les Protéines
Résumé UniProt
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Similitudes de séquence
Belongs to the histone H2B family.
Modification post-traductionnelle
Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
Localisation cellulaire
Nucleus. Chromosome.
