IL2 est un gène codé par le symbole IL2. Communément appelé aussi: Interleukin-2; IL-2; T-cell growth factor; TCGF. IL2 a une masse de 17.63kDa et une longueur d'acide aminé de 153.
Nous proposons 78 des anticorps contre IL2, élevé dans Lapin, Souris, Rat et Poulet, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Porcin, Lapin, Mouton, Poulet, Canin, Furet et Primates.
Informations sur les Gènes et les Protéines
Résumé UniProt
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Résumé Entrez
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
Similitudes de séquence
Belongs to the IL-2 family.
Localisation cellulaire
Secreted.
