ITIH1 est un gène codé par le symbole ITIH1. Communément appelé aussi: Inter-alpha-trypsin inhibitor heavy chain H1; ITI heavy chain H1; Inter-alpha-trypsin inhibitor complex component III; Serum-derived hyaluronan-associated protein; SHAP; IGHEP1. ITIH1 a une masse de 101.39kDa et une longueur d'acide aminé de 911.
Nous proposons 2 des anticorps contre ITIH1, élevé dans Lapin, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain et Souris.
Informations sur les Gènes et les Protéines
Résumé UniProt
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
Résumé Entrez
This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3.
Similitudes de séquence
Belongs to the ITIH family.
Modification post-traductionnelle
Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.
Localisation cellulaire
Secreted.
