Luteinizing Hormone est un gène codé par le symbole LHB. Communément appelé aussi: Lutropin subunit beta; Lutropin beta chain subunit beta; LH-B; LHB. Luteinizing Hormone a une masse de 15.35kDa, une longueur d'acide aminé de 141, et est impliqué dans Hypogonadotropic hypogonadism 23 without anosmia.
Nous proposons 33 des anticorps contre Luteinizing Hormone, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux, IP et RIA avec des échantillons dérivés de Humain, Souris, Rat et Canin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
Résumé Entrez
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism.
Spécificité tissulaire
Pituitary gland.
Implication dans la maladie
Hypogonadotropic hypogonadism 23 without anosmia: A form of hypogonadotropic hypogonadism, a group of disorders characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. HH23 male patients have normal sexual differentiation, reduced or absent Leydig cells, reduced or absent spermatogenesis, and absence of spontaneous puberty. Female patients exhibit normal pubertal development and menarche, followed by oligomenorrhea and anovulatory secondary amenorrhea.
Similitudes de séquence
Belongs to the glycoprotein hormones subunit beta family.
Localisation cellulaire
Secreted.
