MARCKS est un gène codé par le symbole MARCKS. Communément appelé aussi: Myristoylated alanine-rich C-kinase substrate; Protein kinase C substrate, 80 kDa protein, light chain; 80K-L protein; MACS; PRKCSL. MARCKS a une masse de 31.56kDa et une longueur d'acide aminé de 332.
Nous proposons 19 des anticorps contre MARCKS, élevé dans Lapin, Souris et Poulet, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris, Rat et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
Résumé Entrez
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.
Similitudes de séquence
Belongs to the MARCKS family.
Modification post-traductionnelle
Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.
Localisation cellulaire
Cytoplasm > Cytoskeleton. Membrane.
