MMP3 est un gène codé par le symbole MMP3. Communément appelé aussi: Stromelysin-1; SL-1; Matrix metalloproteinase-3; MMP-3; Transin-1; STMY1. MMP3 a une masse de 53.98kDa, une longueur d'acide aminé de 477, et est impliqué dans Coronary heart disease 6.
Nous proposons 25 des anticorps contre MMP3, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
Résumé Entrez
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Implication dans la maladie
Coronary heart disease 6: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries.
Similitudes de séquence
Belongs to the peptidase M10A family.
Localisation cellulaire
Secreted > Extracellular space > Extracellular matrix.
