MMP7 est un gène codé par le symbole MMP7. Communément appelé aussi: Matrilysin; Matrin; Matrix metalloproteinase-7; MMP-7; Pump-1 protease; Uterine metalloproteinase; MPSL1; PUMP1. MMP7 a une masse de 29.68kDa et une longueur d'acide aminé de 267.
Nous proposons 12 des anticorps contre MMP7, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et ChIP avec des échantillons dérivés de Humain, Souris, Rat et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
Résumé Entrez
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers.
Similitudes de séquence
Belongs to the peptidase M10A family.
Localisation cellulaire
Secreted > Extracellular space > Extracellular matrix.
