MTMR3 est un gène codé par le symbole MTMR3. Communément appelé aussi: Myotubularin-related protein 3; FYVE domain-containing dual specificity protein phosphatase 1; FYVE-DSP1; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase; Zinc finger FYVE domain-containing protein 10; KIAA0371; ZFYVE10. MTMR3 a une masse de 133.62kDa et une longueur d'acide aminé de 1198.
Nous proposons 1 des anticorps contre MTMR3, élevé dans Lapin, qui sont appropriés pour le WB et ICC/IF avec des échantillons dérivés de Humain et Souris.
Informations sur les Gènes et les Protéines
Résumé UniProt
Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931).
Résumé Entrez
This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene.
Similitudes de séquence
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Localisation cellulaire
Cytoplasm. Membrane.
