MyoD1 est un gène codé par le symbole MYOD1. Communément appelé aussi: Myoblast determination protein 1; Class C basic helix-loop-helix protein 1; bHLHc1; Myogenic factor 3; Myf-3; BHLHC1; MYF3; MYOD. MyoD1 a une masse de 34.5kDa et une longueur d'acide aminé de 320.
Nous proposons 32 des anticorps contre MyoD1, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris, Rat et Poulet.
Informations sur les Gènes et les Protéines
Résumé UniProt
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).
Résumé Entrez
This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis.
Modification post-traductionnelle
Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation.
Localisation cellulaire
Nucleus.
