Neurochondrin est un gène codé par le symbole NCDN. Communément appelé aussi: NCDN; KIAA0607. Neurochondrin a une masse de 78.86kDa et une longueur d'acide aminé de 729.
Nous proposons 5 des anticorps contre Neurochondrin, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth.
Résumé Entrez
This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described.
Spécificité tissulaire
Abundantly expressed in whole adult brain and in all individual brain regions examined, including spinal cord. Weakly expressed in ovary, testis, fetal brain and small intestine.
Similitudes de séquence
Belongs to the neurochondrin family.
Modification post-traductionnelle
Palmitoylated. Palmitoylation by ZDHHC1, ZDHHC3 and ZDHHC11 regulates the association of NCDN with endosome membranes. May also be palmitoylated by ZDHHC7.
Localisation cellulaire
Cytoplasm > Cytosol. Endosome membrane. Cell projection > Dendrite. Cell junction > Synapse > Postsynapse.
Localizes to somatic regions of neurons. Localization to endosome membrane requires palmitoylation.
