Neuroligin 1 est un gène codé par le symbole NLGN1. Communément appelé aussi: Neuroligin-1; NLGN1; KIAA1070. Neuroligin 1 a une masse de 96.37kDa et une longueur d'acide aminé de 863.
Nous proposons 4 des anticorps contre Neuroligin 1, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep.
Résumé Entrez
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.
Spécificité tissulaire
Expressed in the blood vessel walls (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.
Similitudes de séquence
Belongs to the type-B carboxylesterase/lipase family.
Localisation cellulaire
Cell membrane. Cell junction > Synapse > Postsynaptic density. Cell junction > Synapse > Synaptic cleft. Cell junction > Synapse > Synaptic cell membrane.
Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1.
