P4HA1 est un gène codé par le symbole P4HA1. Communément appelé aussi: Prolyl 4-hydroxylase subunit alpha-1; 4-PH alpha-1; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1; P4HA. P4HA1 a une masse de 61.05kDa et une longueur d'acide aminé de 534.
Nous proposons 2 des anticorps contre P4HA1, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Résumé Entrez
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.
Similitudes de séquence
Belongs to the P4HA family.
Localisation cellulaire
Endoplasmic reticulum lumen.
