PI 3 Kinase Class 3 est un gène codé par le symbole PIK3C3. Communément appelé aussi: Phosphatidylinositol 3-kinase catalytic subunit type 3; PI3-kinase type 3; Phosphatidylinositol 3-kinase p100 subunit; Phosphoinositide-3-kinase class 3; hVps34; PIK3C3; VPS34. PI 3 Kinase Class 3 a une masse de 101.55kDa et une longueur d'acide aminé de 887.
Nous proposons 6 des anticorps contre PI 3 Kinase Class 3, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).
Spécificité tissulaire
Ubiquitously expressed, with a highest expression in skeletal muscle.
Similitudes de séquence
Belongs to the PI3/PI4-kinase family.
Localisation cellulaire
Midbody. Late endosome. Cytoplasmic vesicle > Autophagosome.
As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (Probable). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity).
