PKA regulatory subunit I beta est un gène codé par le symbole PRKAR1B. Communément appelé aussi: cAMP-dependent protein kinase type I-beta regulatory subunit; PRKAR1B. PKA regulatory subunit I beta a une masse de 43.07kDa et une longueur d'acide aminé de 381.
Nous proposons 3 des anticorps contre PKA regulatory subunit I beta, élevé dans Lapin, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
Résumé Entrez
The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene.
Spécificité tissulaire
Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
Similitudes de séquence
Belongs to the cAMP-dependent kinase regulatory chain family.
Modification post-traductionnelle
The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.
Localisation cellulaire
Cell membrane.
