PPP2R5A est un gène codé par le symbole PPP2R5A. Communément appelé aussi: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; PP2A B subunit isoform B'-alpha; PP2A B subunit isoform B56-alpha; PP2A B subunit isoform PR61-alpha; PR61alpha; PP2A B subunit isoform R5-alpha. PPP2R5A a une masse de 56.19kDa et une longueur d'acide aminé de 486.
Nous proposons 6 des anticorps contre PPP2R5A, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Résumé Entrez
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene.
Spécificité tissulaire
Widely expressed with the highest expression in heart and skeletal muscle.
Similitudes de séquence
Belongs to the phosphatase 2A regulatory subunit B56 family.
Modification post-traductionnelle
Phosphorylated on serine residues.
Localisation cellulaire
Cytoplasm. Nucleus. Chromosome > Centromere.
From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase.
