PPP4C est un gène codé par le symbole PPP4C. Communément appelé aussi: Serine/threonine-protein phosphatase 4 catalytic subunit; PP4C; Protein phosphatase X; PP-X; PPP4; PPX. PPP4C a une masse de 35.08kDa et une longueur d'acide aminé de 307.
Nous proposons 6 des anticorps contre PPP4C, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
Similitudes de séquence
Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
Modification post-traductionnelle
Methylation at the C-terminal Leu-307 is critical for interactions with regulatory subunits and functions in DNA repair.
Localisation cellulaire
Cytoplasm. Nucleus. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome.
