Prostate Specific Antigen est un gène codé par le symbole KLK3. Communément appelé aussi: Prostate-specific antigen; PSA; Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase; KLK3; APS. Prostate Specific Antigen a une masse de 28.74kDa et une longueur d'acide aminé de 261.
Nous proposons 50 des anticorps contre Prostate Specific Antigen, élevé dans Lapin, Souris, Chèvre et Sheep, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris et Félin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
Résumé Entrez
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms.
Similitudes de séquence
Belongs to the peptidase S1 family. Kallikrein subfamily.
Localisation cellulaire
Secreted.
