Secretogranin 3 est un gène codé par le symbole SCG3. Il est également connu sous le nom de: Secretogranin-3; Secretogranin III; SgIII; SCG3. Secretogranin 3 a une masse de 53.01kDa et une longueur d'acide aminé de 468.
Nous proposons 4 des anticorps contre Secretogranin 3, élevé dans Lapin, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Member of the granin protein family that regulates the biogenesis of secretory granules (PubMed:19357184). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (PubMed:29154827).
Résumé Entrez
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Expressed in brain, heart, kidney, liver and skeletal muscle.
Modification post-traductionnelle
O-glycosylated.
Localisation cellulaire
Cytoplasmic vesicle > Secretory vesicle. Cytoplasmic vesicle > Secretory vesicle membrane. Secreted.
Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts.
