SIAH Interacting Protein est un gène codé par le symbole CACYBP. Il est également connu sous le nom de: Calcyclin-binding protein; CacyBP; S100A6-binding protein; Siah-interacting protein; CACYBP; S100A6BP; SIP. SIAH Interacting Protein a une masse de 26.21kDa et une longueur d'acide aminé de 228.
Nous proposons 6 des anticorps contre SIAH Interacting Protein, élevé dans Lapin et Souris, qui sont appropriés pour le WB, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
Résumé Entrez
The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Modification post-traductionnelle
Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.
Localisation cellulaire
Nucleus. Cytoplasm.
Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.
