SMC2 est un gène codé par le symbole SMC2. Il est également connu sous le nom de: Structural maintenance of chromosomes protein 2; SMC protein 2; Chromosome-associated protein E; hCAP-E; XCAP-E homolog; CAPEL1. SMC2 a une masse de 135.66kDa et une longueur d'acide aminé de 1197.
Nous proposons 5 des anticorps contre SMC2, élevé dans Lapin, Chèvre et Rat, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain et Souris.
Informations sur les Gènes et les Protéines
Résumé UniProt
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Similitudes de séquence
Belongs to the SMC family. SMC2 subfamily.
Localisation cellulaire
Nucleus. Cytoplasm. Chromosome.
In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
