SMCR7L est un gène codé par le symbole MIEF1. Il est également connu sous le nom de: Mitochondrial dynamics protein MID51; Mitochondrial dynamics protein of 51 kDa; Mitochondrial elongation factor 1; Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like; SMCR7-like protein; MIEF1; MID51. SMCR7L a une masse de 51.29kDa et une longueur d'acide aminé de 463.
Nous proposons 1 des anticorps contre SMCR7L, élevé dans Lapin, qui sont appropriés pour le WB avec des échantillons dérivés de Humain.
Informations sur les Gènes et les Protéines
Résumé UniProt
Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.
Spécificité tissulaire
Expression is relatively high in heart, skeletal muscle, pancreas and kidney.
Similitudes de séquence
Belongs to the SMCR7 family.
Localisation cellulaire
Mitochondrion outer membrane.
