SUZ12 est un gène codé par le symbole SUZ12. Il est également connu sous le nom de: Polycomb protein Chromatin precipitated E2F target 9 protein; ChET 9 protein; Joined to JAZF1 protein; Suppressor of zeste 12 protein homolog; CHET9; JJAZ1; KIAA0160. SUZ12 a une masse de 83.06kDa et une longueur d'acide aminé de 739.
Nous proposons 2 des anticorps contre SUZ12, élevé dans Lapin, qui sont appropriés pour le WB, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Résumé Entrez
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.
Spécificité tissulaire
Overexpressed in breast and colon cancer.
Similitudes de séquence
Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.
Modification post-traductionnelle
Sumoylated, probably by PIAS2.
Localisation cellulaire
Nucleus.
