Synaptophysin est un gène codé par le symbole SYP. Il est également connu sous le nom de: Major synaptic vesicle protein p38; SYP. Synaptophysin a une masse de 33.85kDa, une longueur d'acide aminé de 313, et est impliqué dans Mental retardation, X-linked 96.
Nous proposons 38 des anticorps contre Synaptophysin, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, IP et ChIP avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Singe, Poulet et Hamster.
Informations sur les Gènes et les Protéines
Résumé UniProt
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).
Résumé Entrez
This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with an X-linked form of cognitive disability.
Spécificité tissulaire
Expressed in the brain, with expression in the hippocampus, the neuropil in the dentate gyrus, where expression is higher in the outer half of the molecular layer than in the inner half, and in the neuropil of CA4 and CA3.
Implication dans la maladie
Mental retardation, X-linked 96: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Similitudes de séquence
Belongs to the synaptophysin/synaptobrevin family.
Modification post-traductionnelle
Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Localisation cellulaire
Cytoplasmic vesicle > Secretory vesicle > Synaptic vesicle membrane. Cell junction > Synapse > Synaptosome.
