Thymidine Phosphorylase est un gène codé par le symbole TYMP. Il est également connu sous le nom de: TP; Gliostatin; Platelet-derived endothelial cell growth factor; PD-ECGF; TdRPase; TYMP; ECGF1. Thymidine Phosphorylase a une masse de 49.96kDa, une longueur d'acide aminé de 482, et est impliqué dans Mitochondrial DNA depletion syndrome 1, MNGIE type.
Nous proposons 18 des anticorps contre Thymidine Phosphorylase, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.
Résumé Entrez
This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified.
Implication dans la maladie
Mitochondrial DNA depletion syndrome 1, MNGIE type: A multisystem disease associated with mitochondrial dysfunction. It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, cachexia, peripheral neuropathy, and myopathy.
Similitudes de séquence
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
