TIMP2 est un gène codé par le symbole TIMP2. Il est également connu sous le nom de: Metalloproteinase inhibitor 2; CSC-21K; Tissue inhibitor of metalloproteinases 2; TIMP-2. TIMP2 a une masse de 24.4kDa et une longueur d'acide aminé de 220.
Nous proposons 28 des anticorps contre TIMP2, élevé dans Lapin, Souris et Sheep, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Lapin, Cochon d'Inde et Poisson Zèbre.
Informations sur les Gènes et les Protéines
Résumé UniProt
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
Résumé Entrez
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Similitudes de séquence
Belongs to the protease inhibitor I35 (TIMP) family.
Modification post-traductionnelle
The activity of TIMP2 is dependent on the presence of disulfide bonds.
Localisation cellulaire
Secreted.
