TIMP4 est un gène codé par le symbole TIMP4. Il est également connu sous le nom de: Metalloproteinase inhibitor 4; Tissue inhibitor of metalloproteinases 4; TIMP-4. TIMP4 a une masse de 25.5kDa et une longueur d'acide aminé de 224.
Nous proposons 7 des anticorps contre TIMP4, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
Résumé Entrez
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.
Spécificité tissulaire
Abundant in heart and present at low levels in many other tissues.
Similitudes de séquence
Belongs to the protease inhibitor I35 (TIMP) family.
Localisation cellulaire
Secreted.
