VDAC3 est un gène codé par le symbole VDAC3. Il est également connu sous le nom de: Voltage-dependent anion-selective channel protein 3; VDAC-3; Outer mitochondrial membrane protein porin 3. VDAC3 a une masse de 30.66kDa et une longueur d'acide aminé de 283.
Nous proposons 2 des anticorps contre VDAC3, élevé dans Lapin, qui sont appropriés pour le WB, IHC et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
Résumé Entrez
This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene.
Spécificité tissulaire
Widely expressed. Highest in testis.
Similitudes de séquence
Belongs to the eukaryotic mitochondrial porin family.
Modification post-traductionnelle
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
Localisation cellulaire
Mitochondrion outer membrane.
