Activin A est un gène codé par le symbole INHBA. D'autres noms incluent: Inhibin beta A chain; Activin beta-A chain; Erythroid differentiation protein; EDF; INHBA. Activin A a une masse de 47.44kDa et une longueur d'acide aminé de 426.
Nous proposons 1 Activin A protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Résumé Entrez
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients.
Similitudes de séquence
Belongs to the TGF-beta family.
Localisation cellulaire
Secreted.
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