BNP est un gène codé par le symbole NPPB. D'autres noms incluent: Natriuretic peptides B; Gamma-brain natriuretic peptide; NPPB. BNP a une masse de 14.73kDa et une longueur d'acide aminé de 134.
Nous proposons 3 BNP protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
Résumé Entrez
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis.
Spécificité tissulaire
Brain and also in atria, but at much lower levels than ANP.
Similitudes de séquence
Belongs to the natriuretic peptide family.
Modification post-traductionnelle
The brain natriuretic peptide 32 form is cleaved at Pro-104 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
Localisation cellulaire
Secreted.
Liens de base de données
