CD73 est un gène codé par le symbole NT5E. D'autres noms incluent: 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; NT5E; NT5; NTE. CD73 a une masse de 63.37kDa, une longueur d'acide aminé de 574, et est impliqué dans Calcification of joints and arteries.
Nous proposons 4 CD73 protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.
Résumé Entrez
The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.
Implication dans la maladie
Calcification of joints and arteries: A condition characterized by adult-onset calcification of the lower extremity arteries, including the iliac, femoral and tibial arteries, and hand and foot capsule joints. Age of onset has been reported as early as the second decade of life, usually involving intense joint pain or calcification in the hands.
Similitudes de séquence
Belongs to the 5'-nucleotidase family.
Localisation cellulaire
Cell membrane.
Liens de base de données
