CNTF est un gène codé par le symbole CNTF. Il est également connu sous le nom de Ciliary neurotrophic factor. CNTF a une masse de 22.93kDa et une longueur d'acide aminé de 200.
Nous proposons 7 CNTF protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Résumé Entrez
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.
Spécificité tissulaire
Nervous system.
Similitudes de séquence
Belongs to the CNTF family.
Localisation cellulaire
Cytoplasm.
Liens de base de données
