Enterokinase est un gène codé par le symbole TMPRSS15. D'autres noms incluent: Enteropeptidase; Serine protease 7; Transmembrane protease serine 15; TMPRSS15; ENTK; PRSS7. Enterokinase a une masse de 112.94kDa, une longueur d'acide aminé de 1019, et est impliqué dans Enterokinase deficiency.
Nous proposons 3 Enterokinase protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.
Résumé Entrez
This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive.
Spécificité tissulaire
Intestinal brush border.
Implication dans la maladie
Enterokinase deficiency: Life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive.
Similitudes de séquence
Belongs to the peptidase S1 family.
Modification post-traductionnelle
The chains are derived from a single precursor that is cleaved by a trypsin-like protease.
Localisation cellulaire
Membrane.
Liens de base de données
