GFR alpha 3 est un gène codé par le symbole GFRA3. Communément appelé aussi: GDNF family receptor alpha-3; GDNF receptor alpha-3; GFRA3. GFR alpha 3 a une masse de 44.51kDa et une longueur d'acide aminé de 400.
Nous proposons 1 GFR alpha 3 protéines
Informations sur les Gènes et les Protéines
Résumé UniProt
Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.
Résumé Entrez
The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin.
Spécificité tissulaire
Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system.
Similitudes de séquence
Belongs to the GDNFR family.
Modification post-traductionnelle
N-glycosylated.
Localisation cellulaire
Cell membrane.
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